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Comment
. 2020 Apr:162:108132.
doi: 10.1016/j.diabres.2020.108132. Epub 2020 Mar 29.

COVID-19, diabetes mellitus and ACE2: The conundrum

Rimesh Pal  1 , Anil Bhansali  2
Affiliations
Comment

COVID-19, diabetes mellitus and ACE2: The conundrum

Rimesh Pal et al. Diabetes Res Clin Pract. 2020 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic diagram depicting interplay between SARS-CoV-2 and pneumocyte. SARS-CoV-2 gains entry into the pneumocyte using angiotensin-converting enzyme 2 (ACE2) as a receptor. ACE2 is upregulated with the prior use of angiotensin-converting enzyme inhibitors (ACEi)/angiotensin-receptor blockers (ARBs). Following entry into the pneumocyte, the virus replicates and ACE2 gets downregulated. As a result, there is reduced degradation of angiotensin-II which in turn leads to increased secretion of aldosterone and subsequent renal potassium wasting.
See this image and copyright information in PMC

Comment on

  • Clinical Characteristics of Coronavirus Disease 2019 in China.
    Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Guan WJ, et al. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28. N Engl J Med. 2020. PMID: 32109013 Free PMC article.

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