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. 2020 Mar 29;17(7):2294.
doi: 10.3390/ijerph17072294.

Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

Alessandro Sanduzzi  1 , Emanuele Ciasullo  1 , Ludovica Capitelli  1 , Stefano Sanduzzi Zamparelli  2 , Marialuisa Bocchino  1
Affiliations

Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

Alessandro Sanduzzi et al. Int J Environ Res Public Health. .

Abstract

Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes' predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field.

Keywords: alpha-1-antitrypsin deficiency; bronchiectasis; emphysema; respiratory infections.

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Conflict of interest statement

The authors declare no conflict of interest.

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