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Overall study plan and efficacy results. ( A ) Patient screening and enrollment…
Figure 1
Overall study plan and efficacy results. (A) Patient screening and enrollment flow chart. (B) Cumulative incidence of virologic, clinical, and imaging outcomes. Red color indicates Chloroquine, while blue indicates Lopinavir/Ritonavir. (C) Square root and logarithmic (base 10) transformation were applied to normalize the distribution of CD3+, CD4+, and CD8+ T-cell count data. Missing values of CD3+, CD4+, and CD8+ T-cell counts were imputed by Kalman smoothing on a structural model. The trajectories (with 95% confidence bands) in the Chloroquine group were derived with the use of linear mixed effects model.
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