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. 2020 Jun;46(6):1114-1116.
doi: 10.1007/s00134-020-06026-1. Epub 2020 Mar 31.

Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

Xiu-Wu Pan  1   2 , Da Xu  2   3 , Hao Zhang  4   3 , Wang Zhou  5   6 , Lin-Hui Wang  7 , Xin-Gang Cui  8
Affiliations

Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

Xiu-Wu Pan et al. Intensive Care Med. 2020 Jun.
No abstract available

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Conflict of interest statement

All authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Identification of kidney host cells by scRNA-seq analysis. a Feature plots show the expression of ACE2 (red) and TMPRSS genes (blue) in kidney epithelial cells. The merged image shows the coexpression of ACE2 and TMPRSS genes, especially in proximal tubules and podocytes. b Box plots show the expression of ACE2 and the mean expression of the TMPRSS family genes in the 19 clusters of kidney cells. The expression is presented as the log2 (TP10K + 1) value
See this image and copyright information in PMC

References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed
    1. Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, Liu L, Shan H, Lei C-L, Hui DSC, Du B, Li L-J, Zeng G, Yuen K-Y, Chen R-C, Tang C-L, Wang T, Chen P-Y, Xiang J, Li S-Y, Wang J-L, Liang Z-J, Peng Y-X, Wei L, Liu Y, Hu Y-H, Peng P, Wang J-M, Liu J-Y, Chen Z, Li G, Zheng Z-J, Qiu S-Q, Luo J, Ye C-J, Zhu S-Y, Zhong N-S. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 doi: 10.1056/NEJMoa2002032. - DOI - PMC - PubMed
    1. Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020 doi: 10.1007/s00134-020-05985-9. - DOI - PMC - PubMed
    1. Jefferson JA, Nelson PJ, Najafian B, Shankland SJ. Podocyte disorders: core curriculum 2011. Am J Kidney Dis. 2011;58(4):666–677. doi: 10.1053/j.ajkd.2011.05.032. - DOI - PMC - PubMed

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