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Comment
. 2020 Jun;35(3):340-343.
doi: 10.1007/s12250-020-00214-5. Epub 2020 Mar 31.

Inefficiency of Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV Infection

Zezhong Liu  1 , Shuai Xia  1 , Xinling Wang  1 , Qiaoshuai Lan  1 , Wei Xu  1 , Qian Wang  1 , Shibo Jiang  2 , Lu Lu  3
Affiliations
Comment

Inefficiency of Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV Infection

Zezhong Liu et al. Virol Sin. 2020 Jun.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Neutralizing effects of sera from mice treated with SARS-PsV or MERS-PsV against SARS-PsV, MERS-PsV, 2019-nCoV-PsV, WIV1-PsV and Rs3367-PsV infection. A Schematic representation of the production of SARS-PsV and MERS-PsV. B The immunization procedure. C Detection of sera from SARS-PsV-, MERS-PsV- and PBS-treated mice for neutralization activity against SARS-PsV infection. D Assessment of sera from SARS-PsV-treated mice for neutralizing antibody titers against SARS-PsV infection. E Detection of sera from SARS-PsV-, MERS-PsV- and PBS-treated mice for neutralizing antibody titers against MERS-PsV infection. F Assessment of sera from MERS-PsV-treated mice for the neutralizing antibody titers against MERS-PsV infection. G Detection of sera from SARS-PsV-, MERS-PsV- and PBS-treated mice for neutralization activity against 2019-nCoV-PsV infection. H–I Detection of sera from SARS-PsV-, MERS-PsV- and PBS-treated mice for neutralization activity against WIV1-PsV and Rs3367-PsV, respectively. J–K Detection of sera from SARS-PsV-treated mice for neutralization activity against WIV1-PsV and Rs3367-PsV infection. I NT50 value of mouse sera agaisnt SARS-PsV, MERS-PsV, WIV1-PsV, Rs3367-PsV and 2019-nCoV-PsV infection. GraphPad Prism version 5.0 was used to perform all statistical analyses. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
See this image and copyright information in PMC

Comment on

  • A pneumonia outbreak associated with a new coronavirus of probable bat origin.
    Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. Zhou P, et al. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. Nature. 2020. PMID: 32015507 Free PMC article.

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