Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug;96(2):714-730.
doi: 10.1111/cbdd.13685. Epub 2020 May 14.

Isoniazid-phytochemical conjugation: A new approach for potent and less toxic anti-TB drug development

Shasank S Swain  1   2 , Sudhir K Paidesetty  3 , Rabindra N Padhy  2 , Tahziba Hussain  1
Affiliations
Review

Isoniazid-phytochemical conjugation: A new approach for potent and less toxic anti-TB drug development

Shasank S Swain et al. Chem Biol Drug Des. 2020 Aug.

Abstract

Mycobacterium tuberculosis (Mtb) causes one of the most grievous pandemic infectious diseases, tuberculosis (TB), with long-term morbidity and high mortality. The emergence of drug-resistant Mtb strains, and the co-infection with human immunodeficiency virus, challenges the current WHO-TB stewardship programs. The first-line anti-TB drugs, isoniazid (INH) and rifampicin (RIF), have become extensively obsolete in TB control from chromosomal mutations during the last decades. However, based on clinical trial statistics, the production of well-tolerated anti-TB drug(s) is miserably low. Alternately, semi-synthesis or structural modifications of first-line obsolete antitubercular drugs remain as the versatile approach for getting some potential medicines. The use of any suitable phytochemicals with INH in a hybrid formulation could be an ideal approach for the development of potent anti-TB drug(s). The primary objective of this review was to highlight and analyze available INH-phytochemical hybrid research works. The utilization of phytochemicals through chemical conjugation is a new trend toward the development of safer/non-toxic anti-TB drugs.

Keywords: Mycobacterium tuberculosis; INH-phytochemical hybrid; co-infection with human immunodeficiency virus; first-line anti-TB drugs.

PubMed Disclaimer

References

REFERENCES

    1. Aboul-Fadl, T., Mohammed, F. A., & Hassan, E. A. (2003). Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisation and isonicotinic acid hydrazide (INH). Archives of Pharmacal Research, 26, 778-784. https://doi.org/10.1007/bf02980020
    1. Al-Humadi, H. W., Al-Saigh, R. J., & Al-Humadi, A. W. (2017). Addressing the challenges of tuberculosis: A brief historical account. Frontiers in Pharmacology, 8, 689. https://doi.org/10.3389/fphar.2017.00689
    1. Ali-Seyed, M., Jantan, I., Vijayaraghavan, K., & Bukhari, S. N. (2016). Betulinic acid: Recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy. Chemical Biology & Drug Design, 87, 517-536. https://doi.org/10.1111/cbdd.12682
    1. Ando, H., Kitao, T., Miyoshi-Akiyama, T., Kato, S., Mori, T., & Kirikae, T. (2011). Down regulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis. Molecular Microbiology, 79, 1615-1628. https://doi.org/10.1111/j.1365-2958.2011.07547.x
    1. Andreeva, O. V., Sharipova, R. R., Strobykina, I. Y., Lodochnikova, O. A., Dobrynin, A. B., Babaev, V. M., … Kataev, V. E. (2011). Hybrid compounds of ent-beyerane diterpenoid isosteviol with pyridine carboxylic acid hydrazides. Synthesis, structure, and antitubercular activity. Russian Journal of General Chemistry, 81(8), 1643-1650. https://doi.org/10.1134/S1070363211080111

Publication types

MeSH terms

LinkOut - more resources