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Comment
. 2020 Apr;10(4):492-494.
doi: 10.1158/2159-8290.CD-20-0037.

Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction

Michael R Green  1   2 , Sattva S Neelapu  3
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Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction

Michael R Green et al. Cancer Discov. 2020 Apr.

Abstract

In this issue, Singh and colleagues describe a novel tumor-intrinsic mechanism of resistance to chimericantigen receptor (CAR) T-cell therapy targeting CD19 in B-cell malignancies. They show that reduced expression of death receptor genes in the tumors mediates resistance to killing by CAR T cells, leads to progressive CAR T-cell dysfunction, and is associated with unfavorable clinical outcome in patients.See related article by Singh et al., p. 552.

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