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. 2020 Apr 1;10(1):5783.
doi: 10.1038/s41598-020-62805-2.

Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome - a pilot study

Wolfgang Lederer #  1 , Helene Schaffenrath  2 , Cristina Alomar-Dominguez #  3 , Julia Thaler  3 , Raffaella Fantin  3 , Lucie Dostal  4 , Guenther Putz  3 , Christian Humpel #  5
Affiliations

Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome - a pilot study

Wolfgang Lederer et al. Sci Rep. .

Abstract

During pregnancy, substantial alterations in cerebral plasticity, vascular remodeling and neuronal growth occur in the maternal brain. We investigated whether concentrations of selected neurodiagnostic biomarkers in the cerebrospinal fluid of women with preeclampsia/HELLP syndrome differ from those in healthy controls using enzyme-linked immunosorbent assay technique. We found that tau protein concentrations (p = 0.016) and phospho-tau/tau ratio (p < 0.001) in cerebrospinal fluid were significantly lower in 39 preeclamptic women compared to 44 healthy controls during third trimester of pregnancy. Beta-amyloid(1-40)/(1-42) ratio was significantly higher in HELLP syndrome than in severe preeclampsia (8.49 + 2.73 vs. 4.71 + 1.65; p = 0.007). We conclude that beta-amyloid(1-40)/(1-42) ratio in cerebrospinal fluid can discriminate severe preeclampsia and HELLP syndrome. High beta-amyloid peptide and low tau protein concentrations are associated with impaired development of the materno-feto-placental unit and correlate with placental dysfunction.

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Conflict of interest statement

The authors declare that they have no conflict of financial and non-financial interests including personal relationships with other persons or organizations that could inappropriately influence, or be perceived to influence, the work.

Figures

Figure 1
Figure 1
CONSORT 2010 Flow Diagram of patient enrolment.
See this image and copyright information in PMC

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