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Review
. 2020 Apr;14(2):126-135.
doi: 10.1007/s11684-020-0767-8. Epub 2020 Apr 2.

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou  1   2   3 , Xinxin Zhang  1   4 , Jieming Qu  5   6   7
Affiliations
Review

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou et al. Front Med. 2020 Apr.

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

Keywords: clinical characteristics; coronavirus disease 2019; epidemiology; pathology; radiology; treatment.

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Conflict of interest statement

Min Zhou, Xinxin Zhang, and Jieming Qu declare that they have no conflict of interest. This manuscript is a review article that does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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