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Review
. 2020 Sep;37(5):228-233.
doi: 10.1053/j.semdp.2020.03.002. Epub 2020 Mar 17.

The evolving concept of aggressive histological variants of differentiated thyroid cancer

Juan C Hernandez-Prera  1
Affiliations
Review

The evolving concept of aggressive histological variants of differentiated thyroid cancer

Juan C Hernandez-Prera. Semin Diagn Pathol. 2020 Sep.

Abstract

It is recommended by current clinical guidelines that pathologists identify and report aggressive histological variants of differentiated thyroid cancer (e.g., tall cell, columnar cell, and hobnail variants of papillary thyroid carcinoma; widely invasive follicular thyroid carcinoma). This review analyzes the historical evolution of these entities and highlights unresolved issues with respect to the diagnostic criteria for these tumors.

Keywords: Follicular thyroid carcinoma; Histological variants; Papillary thyroid carcinoma.

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