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Editorial
. 2020 Apr 23;55(4):2000749.
doi: 10.1183/13993003.00749-2020. Print 2020 Apr.

Will children reveal their secret? The coronavirus dilemma

Luca Cristiani  1 , Enrica Mancino  1 , Luigi Matera  1 , Raffaella Nenna  1 , Alessandra Pierangeli  2 , Carolina Scagnolari  2 , Fabio Midulla  1
Affiliations
Editorial

Will children reveal their secret? The coronavirus dilemma

Luca Cristiani et al. Eur Respir J. .

Abstract

Epidemiological evidences show that SARS-CoV-2 infection in children is less frequent and severe than adults. Age-related ACE2 receptor expression, lymphocyte count and trained immunity might be the keystone to reveal children's secret.

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Conflict of interest statement

Conflict of interest: L. Cristiani has nothing to disclose. Conflict of interest: E. Mancino has nothing to disclose. Conflict of interest: L. Matera has nothing to disclose. Conflict of interest: R. Nenna has nothing to disclose. Conflict of interest: A. Pierangeli has nothing to disclose. Conflict of interest: C. Scagnolari has nothing to disclose. Conflict of interest: F. Midulla has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
The figure illustrates the theoretical constructs and putative immunological and pathogenetic differences between children and adults relative to SARS-CoV-2 infection Legend: unlike adults, children show constitutionally elevated ACE2 expression and lymphocyte count. Moreover, they undergo several viral infections and scheduled immunizations, which may boost their innate and adaptive immunity.
See this image and copyright information in PMC

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References

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