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. 2020 Jun;16(6):297-298.
doi: 10.1038/s41574-020-0353-9.

Endocrine and metabolic link to coronavirus infection

Affiliations

Endocrine and metabolic link to coronavirus infection

Stefan R Bornstein et al. Nat Rev Endocrinol. 2020 Jun.

Abstract

Type 2 diabetes mellitus and hypertension are the most common comorbidities in patients with coronavirus infections. Emerging evidence demonstrates an important direct metabolic and endocrine mechanistic link to the viral disease process. Clinicians need to ensure early and thorough metabolic control for all patients affected by COVID-19.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Yang JK, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet. Med. 2006;23:623–628. doi: 10.1111/j.1464-5491.2006.01861.x. - DOI - PubMed
    1. Kulcsar KA, Coleman CM, Beck SE, Frieman MB. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight. 2019;4:131774. doi: 10.1172/jci.insight.131774. - DOI - PMC - PubMed
    1. Mehta D, et al. Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 doi: 10.1016/S0140-6736(20)30628-0. - DOI - PMC - PubMed
    1. Hoffmann M, et al. SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 doi: 10.1016/j.cell.2020.02.05. - DOI - PMC - PubMed
    1. Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1–7) and Mas receptor axis in inflammation and fibrosis. Br. J. Pharmacol. 2013;169:477–492. doi: 10.1111/bph.12159. - DOI - PMC - PubMed

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