Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul;28(7):849-850.
doi: 10.1038/s41431-020-0615-y. Epub 2020 Apr 2.

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Lies Van Horebeek  1   2 , An Goris  3   4
Affiliations
Comment

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Lies Van Horebeek et al. Eur J Hum Genet. 2020 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Detection of allele-specific expression of LIME1.
Gene structure with exons and introns for part of LIME1 (not on scale) and two coding variants in linkage disequilibrium with the MS-associated variant rs2256814. MS risk allele is associated with opposite effects for different transcripts, i.e., with reduced expression of transcripts containing rs2236510 and increased expression of transcripts containing rs914559.
See this image and copyright information in PMC

Comment on

References

    1. Ban M, Liao W, Baker A, Thorpe J, Molyneux P, Fraser M, et al. Transcript specific regulation of expression influences susceptibility to multiple sclerosis. Eur J Hum Genet. 2020. in press. - PMC - PubMed
    1. Park E, Pan Z, Zhang Z, Lin L, Xing Y. The expanding landscape of alternative splicing variation in human populations. Am J Hum Genet. 2018;102:11–26. doi: 10.1016/j.ajhg.2017.11.002. - DOI - PMC - PubMed
    1. Li YI, van de Geijn B, Raj A, Knowles DA, Petti AA, Golan D, et al. RNA splicing is a primary link between genetic variation and disease. Science. 2016;352:600–4. doi: 10.1126/science.aad9417. - DOI - PMC - PubMed
    1. Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, et al. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet. 2017;49:600–5. doi: 10.1038/ng.3795. - DOI - PMC - PubMed
    1. The International Multiple Sclerosis Genetics Consortium. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019;365:eaav7188. doi: 10.1126/science.aav7188. - DOI - PMC - PubMed

Publication types