Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 1;5(7):747-748.
doi: 10.1001/jamacardio.2020.1329.

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science

Affiliations

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science

Majd AlGhatrif et al. JAMA Cardiol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.
Schematic of Inflammatory Profile Before and After Coronavirus Disease 2019 (COVID-19) Infection Simplified schematic of the preinfection inflammatory profile among predisposed older individuals vs their younger counterparts. ACE2 indicates angiotensin-converting enzyme 2; CVD, cardiovascular disease; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Similar articles

  • COVID-19 and the Heart.
    Strabelli TMV, Uip DE. Strabelli TMV, et al. Arq Bras Cardiol. 2020 Apr;114(4):598-600. doi: 10.36660/abc.20200209. Epub 2020 Mar 30. Arq Bras Cardiol. 2020. PMID: 32236325 English, Portuguese. No abstract available.
  • COVID-19 in patients with cardiovascular diseases.
    Hulot JS. Hulot JS. Arch Cardiovasc Dis. 2020 Apr;113(4):225-226. doi: 10.1016/j.acvd.2020.03.009. Epub 2020 Mar 31. Arch Cardiovasc Dis. 2020. PMID: 32245656 Free PMC article. No abstract available.
  • Cardiovascular disease, heart failure and COVID-19.
    Faconti L, Chowienczyk PJ, Shah AM. Faconti L, et al. J Renin Angiotensin Aldosterone Syst. 2020 Apr-Jun;21(2):1470320320926903. doi: 10.1177/1470320320926903. J Renin Angiotensin Aldosterone Syst. 2020. PMID: 32434431 Free PMC article. No abstract available.
  • Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019.
    Li L, Zhou Q, Xu J. Li L, et al. Biomed Res Int. 2020 May 26;2020:7413673. doi: 10.1155/2020/7413673. eCollection 2020. Biomed Res Int. 2020. PMID: 32596365 Free PMC article. Review.
  • COVID-19 and the Heart.
    Akhmerov A, Marbán E. Akhmerov A, et al. Circ Res. 2020 May 8;126(10):1443-1455. doi: 10.1161/CIRCRESAHA.120.317055. Epub 2020 Apr 7. Circ Res. 2020. PMID: 32252591 Review.

Cited by

References

    1. Bozkurt B, Kovacs R, Harrington B. HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19 Accessed March 22, 2020. https://professional.heart.org/professional/ScienceNews/UCM_505836_ HFSA... - PMC - PubMed
    1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation 2003;107(2):346–354. doi:10.1161/01.CIR.0000048893.62841.F7 - DOI - PubMed
    1. Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med 2005;11 (8):875–879. doi:10.1038/nm1267 - DOI - PMC - PubMed
    1. Xie X, Chen J, Wang X, Zhang F, Liu Y. Age- and gender-related difference of ACE2 expression in rat lung. Life Sci 2006;78(19):2166–2171. Published correction appears in Life Sci. 2006;79(26):2499. doi:10.1016/j.lfs.2005.09.038 - DOI - PMC - PubMed
    1. Lakatta EG. The reality of getting old. Nat Rev Cardiol 2018;15(9):499–500. doi:10.1038/s41569-018-0068-y - DOI - PubMed

Substances