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Review
. 2020 Nov 1;16(11):2816-2821.
doi: 10.1080/21645515.2020.1741997. Epub 2020 Apr 3.

Review of long term immunogenicity and tolerability of live hepatitis A vaccine

Nitin Shah  1 , Mma Faridi  2 , Monjori Mitra  3 , Ashish Bavdekar  4 , Archana Karadkhele  5 , Gaurav Puppalwar  5 , Rishi Jain  5
Affiliations
Review

Review of long term immunogenicity and tolerability of live hepatitis A vaccine

Nitin Shah et al. Hum Vaccin Immunother. .

Abstract

Hepatitis A represents one of the major public health problems worldwide including India. Vaccination is the most effective way to prevent hepatitis A infection. Two types of hepatitis A vaccines-live attenuated (H2 strain) and inactivated (killed) are available for use in clinical practice in India with former having advantage of a single-dose compared to two-dose killed vaccine. One of the important characteristic of an ideal vaccine includes its ability to provide life-long protection. In this article we reviewed the available long-term (≥10 years follow-up) published data on live attenuated hepatitis A (H2 strain) vaccine. The data from country of origin of the vaccine (China) and India establish the long-term immunogenicity, protection, and tolerability. Based on the results of several clinical trials showing long-term protection, single dose of live attenuated hepatitis vaccine can be widely used to protect high-risk population against hepatitis A virus infection and related complications.

Keywords: hepatitis A vaccine; immunogenicity; live attenuated; tolerability.

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