Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul;92(1):e12883.
doi: 10.1111/sji.12883. Epub 2020 May 5.

Pattern of human monocyte subpopulations in health and disease

Agnieszka Ożańska  1 , Donata Szymczak  1 , Justyna Rybka  1
Affiliations
Free article
Review

Pattern of human monocyte subpopulations in health and disease

Agnieszka Ożańska et al. Scand J Immunol. 2020 Jul.
Free article

Abstract

Monocytes are important cells of the innate system. They are a heterogeneous type of cells consisting of phenotypically and functionally distinct subpopulations, which play a specific role in the control, development and escalation of the immunological processes. Based on the expression of superficial CD14 and CD16 in flow cytometry, they can be divided into three subsets: classical, intermediate and non-classical. Variation in the levels of human monocyte subsets in the blood can be observed in patients in numerous pathological states, such as infections, cardiovascular and inflammatory diseases, cancer and autoimmune diseases. The aim of this review is to summarize current knowledge of human monocyte subsets and their significance in homeostasis and in pathological conditions.

Keywords: CD14; CD16; classical monocytes; intermediate monocytes; monocyte classification; monocyte subsets; non-classical monocytes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Vlacil AK, Schuett J, Schieffer B, Grote K. Variety matters: diverse functions of monocyte subtypes in vascular inflammation and atherogenesis. Vascul Pharmacol. 2019;113:9-19.
    1. Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11(11):762-774.
    1. Ginhoux F, Guilliams M. Tissue-resident macrophage ontogeny and homeostasis. Immunity. 2016;44(3):439-449.
    1. Wong KL, Yeap WH, Tai JJY, Ong SM, Dang TM, Wong SC. The three human monocyte subsets: implications for health and disease. Immunol Res. 2012;53(1-3):41-57.
    1. Lund H, Boysen P, Åkesson CP, Lewandowska-Sabat AM, Storset AK. Transient migration of large numbers of CD14++ CD16+ monocytes to the draining lymph node after onset of inflammation. Front Immunol. 2016;7:322.

MeSH terms

Substances

LinkOut - more resources