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Case Reports
. 2020 Jul;20(7):1879-1881.
doi: 10.1111/ajt.15896. Epub 2020 Apr 17.

COVID-19 in posttransplant patients-report of 2 cases

Jiaofeng Huang  1 , Heng Lin  2 , Yinlian Wu  1 , Yingying Fang  3 , Rahul Kumar  4 , Gongping Chen  5 , Su Lin  1
Affiliations
Case Reports

COVID-19 in posttransplant patients-report of 2 cases

Jiaofeng Huang et al. Am J Transplant. 2020 Jul.

Abstract

Coronavirus Disease 2019 (COVID-19) has become a pandemic since March 2020. We describe here 2 cases of COVID-19 infection in a posttransplant setting. First one is a 59-year-old renal transplant recipient; the second is a 51-year-old allogeneic bone marrow transplant recipient. Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. After the diagnosis of COVID-19, immunosuppressive agents were discontinued and methylprednisolone with prophylactic antibiotics were initiated, however, the lung injury progressed. The T cells were extremely low in both patients after infection. Both patients died despite the maximal mechanical ventilatory support. Therefore, the prognosis of COVID-19 pneumonia following transplantation is not optimistic and remains guarded. Lower T cell count may be a surrogate for poor outcome.

Keywords: COVID-19; Coronavirus; transplantation.

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