Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Lars Fugger¹, Lise Torp Jensen², Jamie Rossjohn³

Affiliations

¹ Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark. Electronic address: lars.fugger@imm.ox.ac.uk.
² Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
³ Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address: jamie.rossjohn@monash.edu.

PMID: 32243797
DOI: 10.1016/j.cell.2020.03.007

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Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Lars Fugger et al. Cell. 2020.

Free article

. 2020 Apr 2;181(1):63-80.

doi: 10.1016/j.cell.2020.03.007.

Authors

Lars Fugger¹, Lise Torp Jensen², Jamie Rossjohn³

Affiliations

¹ Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark. Electronic address: lars.fugger@imm.ox.ac.uk.
² Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
³ Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address: jamie.rossjohn@monash.edu.

PMID: 32243797
DOI: 10.1016/j.cell.2020.03.007

Abstract

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

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Conflict of interest statement

Declaration of Interests J.R. has received funds to work on autoimmune diseases from Janssen Research & Development, LLC.

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Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

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Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

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