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. 2020 Apr 2;181(1):7.
doi: 10.1016/j.cell.2020.02.033.

A New Rapid-Acting Antidepressant

John H Krystal  1 , Dennis S Charney  2 , Ronald S Duman  2
Affiliations
Free article

A New Rapid-Acting Antidepressant

John H Krystal et al. Cell. .
Free article

Abstract

The discovery of the strikingly rapid and robust antidepressant effects of r/s-ketamine for the treatment of antidepressant-resistant symptoms of depression has led to new insights into the biology of antidepressants and the FDA approval of its s-isomer, Esketamine (Spravato), the first mechanistically new treatment for depression in over 60 years. To view this Bench to Bedside, open or download the PDF.

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