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. 2020 May;30(5):449-451.
doi: 10.1038/s41422-020-0310-0. Epub 2020 Apr 3.

Cryo-EM structures of human pannexin 1 channel

Qiuheng Jin #  1 , Bo Zhang #  1 , Xiang Zheng #  2 , Ningning Li #  3 , Lingyi Xu  4   5 , Yuan Xie  4   5 , Fangjun Song  4   5 , Eijaz Ahmed Bhat  1 , Yuan Chen  2 , Ning Gao  3 , Jiangtao Guo  6   7 , Xiaokang Zhang  8 , Sheng Ye  9   10
Affiliations

Cryo-EM structures of human pannexin 1 channel

Qiuheng Jin et al. Cell Res. 2020 May.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Cryo-EM structure of human Pannexin 1 (PANX1) channel.
a The Cryo-EM density map of PANX1EE viewed parallel to the plasma membrane. b, c Ribbon representations of the heptameric structure of PANX1EE viewed parallel to the plasma membrane (b) or from the extracellular side down the sevenfold symmetry axis (c). d Ribbon representation of the protomer structure of PANX1EE. e Schematic representation of the PANX1 topology. Gray lines indicate the estimated lipid bilayer borders. f A zoom in view of the subunits interface with interactions labeled. g Ribbon representation of the channel pore with the substrate conduction pathway displayed in gray mesh. Key domains and residues are labeled. h The pore radius along the substrate conduction pathway calculated by HOLE program. Residues forming the constrictions are labeled. i, j The Cryo-EM density maps of the extracellular gate in PANX1EE (i) or PANX1CBX (j). The density corresponding to CBX is highlighted in red box. k Representation of single subunit of a superimposed overall structure of PANX1EE (yellow) and PANX1CBX (cyan). l Representation of single subunit of a superimposed overall structure of PANX1EE (yellow) and PANX1WT (green).
See this image and copyright information in PMC

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