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. 2020 Apr 3;4(1):23.
doi: 10.1186/s41687-020-00188-8.

Development of a multiplicative, multi-attribute utility function and eight single-attribute utility functions for the Health Utilities Index Mark 3 in Japan

Shinichi Noto  1 , Takeru Shiroiwa  2 , Makoto Kobayashi  3 , Tatsunori Murata  3 , Shunya Ikeda  4 , Takashi Fukuda  2
Affiliations

Development of a multiplicative, multi-attribute utility function and eight single-attribute utility functions for the Health Utilities Index Mark 3 in Japan

Shinichi Noto et al. J Patient Rep Outcomes. .

Abstract

Background: The Health Utilities Index Mark 3 (HUI3) is a generic multi-attribute, preference-based system for assessing health-related quality of life. It is widely used overseas as an outcome measure and for estimating quality-adjusted life years. We aimed to estimate a multi-attribute and eight single-attribute utility functions for the HUI3 system based on community preferences in Japan. We conducted two preference surveys in this study. The first survey was designed to estimate a model of utility function and collect preference scores, and the second survey was designed to evaluate predictive validity of the utility function and provide independent scores. Values obtained from the feeling thermometer and standard gamble scores obtained from using a chance board were included in the preference scale. We recruited 1043 respondents (age: 20-79 years) from five cities in Japan through the general population classified by sex and age groups. Respondents were further randomly divided into a modeling group (n = 774) and a direct group (n = 263).

Results: We acquired the estimation for eight single-attribute and a global multi-attribute utility function. The minimum expected multi-attribute utility score was - 0.002. The intraclass correlation coefficient between the directly measured utility score and the score generated by multi-attribute function in terms of 53 health conditions was 0.742.

Conclusions: The HUI3 scoring function developed in Japan has a strong theoretical and empirical basis. It will be useful in future to predict the directly measured score of health technology assessments in Japan.

Keywords: Health utilities index; Health utilities index mark 3; Health-related quality of life; Preference-based measure; Quality-adjusted life year; Standard gamble.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the survey
Fig. 2
Fig. 2
External agreement (SG scores vs scores using MAUF)
See this image and copyright information in PMC

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