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. 2020 Mar;168(5):651-653.
doi: 10.1007/s10517-020-04772-2. Epub 2020 Apr 4.

Effects of Humic Acids, Isolated from High-Moor Pine-Peat Moss-Cotton Grass Peat on the Production of Cytokines by Mouse and Human Immunocompetent Cells and on Humoral Immune Response

E S Trofimova  1 , M V Zykova  2 , E Yu Sherstoboev  3 , M G Danilets  3 , A A Ligacheva  3 , M V Belousov  2   4
Affiliations

Effects of Humic Acids, Isolated from High-Moor Pine-Peat Moss-Cotton Grass Peat on the Production of Cytokines by Mouse and Human Immunocompetent Cells and on Humoral Immune Response

E S Trofimova et al. Bull Exp Biol Med. 2020 Mar.

Abstract

A course of treatment with humic acids extracted with sodium pyrophosphate from high-moor pine-peat moss-cotton grass peat improves humoral immune response of C57BL/6 mice, stimulates the production of TNFα, IL-1β, and IL-12 by the animal peritoneal macrophages and the production of IFNγ and TNFα by donor peripheral blood mononuclears, causing no changes in the production of IL-10 in vitro.

Keywords: cytokines; humic acids; humoral immune response.

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