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Practice Guideline
. 2020 Apr;18(4):400-413.
doi: 10.1111/ddg.14072. Epub 2020 Apr 4.

S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) - short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow-up, prevention and occupational disease

Ulrike Leiter  1 , Markus V Heppt  2   3 , Theresa Steeb  2   3 , Teresa Amaral  1 , Andrea Bauer  4 , Jürgen C Becker  5 , Eckhardt Breitbart  6 , Helmut Breuninger  1 , Thomas Diepgen  7 , Thomas Dirschka  8 , Thomas Eigentler  1 , Michael Flaig  2 , Markus Follmann  9 , Klaus Fritz  10 , Rüdiger Greinert  6 , Ralf Gutzmer  11 , Uwe Hillen  12 , Stephan Ihrler  13 , Swen Malte John  14 , Oliver Kölbl  15 , Klaus Kraywinkel  16 , Christoph Löser  17 , Dorothee Nashan  18 , Seema Noor  1 , Monika Nothacker  19 , Christina Pfannenberg  20 , Carmen Salavastru  10 , Lutz Schmitz  21 , Eggert Stockfleth  21 , Rolf-Markus Szeimies  22 , Claas Ulrich  23 , Julia Welzel  24 , Kai Wermker  25 , Claus Garbe  1 , Carola Berking  2   3
Affiliations
Practice Guideline

S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) - short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow-up, prevention and occupational disease

Ulrike Leiter et al. J Dtsch Dermatol Ges. 2020 Apr.

Abstract

Actinic keratoses (AKs) are common lesions in light-skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence-based framework for clinical decision making, the guidelines for actinic keratosis and cutaneous squamous cell carcinoma were developed using the highest level of methodology (S3) according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF). The guidelines are aimed at dermatologists, general practitioners, ENT specialists, surgeons, oncologists, radiologists and radiation oncologists in hospitals and office-based settings as well as other medical specialties involved in the diagnosis and treatment of patients with AKs and cSCC. The guidelines are also aimed at affected patients, their relatives, policy makers and insurance funds. In the second part, we will address aspects relating to epidemiology, etiology, surgical and systemic treatment of cSCC, follow-up and disease prevention, and discuss AKs and cSCC in the context of occupational disease regulations.

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References

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    1. Togsverd-Bo K, Lei U, Erlendsson AM et al. Combination of ablative fractional laser and daylight-mediated photodynamic therapy for actinic keratosis in organ transplant recipients - a randomized controlled trial. Br J Dermatol 2015; 172: 467-74.
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    1. Krediet JT, Beyer M, Lenz K et al. Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma. Br J Dermatol 2015; 172: 1029-36.

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