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Observational Study
. 2021 Jan 1;41(1):82-92.
doi: 10.1097/IAE.0000000000002806.

INTRARETINAL HYPERREFLECTIVE LINES

Francesca Amoroso  1 , Sarah Mrejen  2 , Alexandre Pedinielli  1 , Sandrine Tabary  2 , Eric H Souied  1 , Alain Gaudric  2   3 , Salomon Y Cohen  1   2
Affiliations
Observational Study

INTRARETINAL HYPERREFLECTIVE LINES

Francesca Amoroso et al. Retina. .

Abstract

Purpose: To report intraretinal hyperreflective lines related to various macular conditions.

Methods: All cases were imaged with color photographs, autofluorescence images, and spectral-domain optical coherence tomography, some with fluorescein and/or indocyanine green angiography. Demographic data, imaging, course and outcome were retrospectively analyzed.

Results: Forty-nine eyes of 43 patients (16 men and 27 women) were included. Hyperreflective vertical lines (38 eyes) or curvilinear lines along the Henle fiber layer (11 eyes) were present in association with various macular conditions: adult vitelliform dystrophy or pattern dystrophy (24 eyes) frequently associated with an epiretinal membrane (six eyes) and/or thick choroid (nine eyes), age-related maculopathy or macular degeneration (nine eyes), partial resorption of subretinal or intraretinal hemorrhages (five eyes), idiopathic macular microhole (two eyes), vitreomacular traction (three eyes), multiple evanescent white dot syndrome (three eyes), fundus flavimaculatus (two eyes), and pachychoroid pigment epitheliopathy (one eye). The lines fully vanished in cases of hemorrhages, multiple evanescent white dot syndrome or resolution of vitreomacular traction, but usually persisted with gradual thinning in the other conditions.

Conclusion: The present series showed that intraretinal hyperreflective lines could occur in various inflammatory, degenerative, or tractional conditions. They could reflect a previously unrecognized reaction to various photoreceptor, Müller cell, and/or retinal pigment epithelium damage.

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Comment in

  • Correspondence.
    Arrigo A, Pierro L, Marchese A, Bandello F. Arrigo A, et al. Retina. 2021 Feb 1;41(2):e19. doi: 10.1097/IAE.0000000000002929. Retina. 2021. PMID: 32740490 No abstract available.
  • Reply.
    Cohen SY, Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A. Cohen SY, et al. Retina. 2021 Feb 1;41(2):e19-e20. doi: 10.1097/IAE.0000000000002928. Retina. 2021. PMID: 32740493 No abstract available.
  • Reply.
    Cohen SY, Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A. Cohen SY, et al. Retina. 2021 Feb 1;41(2):e22-e23. doi: 10.1097/IAE.0000000000002935. Retina. 2021. PMID: 32769713 No abstract available.
  • Correspondence.
    Scarinci F, Lombardo M. Scarinci F, et al. Retina. 2021 Feb 1;41(2):e20-e22. doi: 10.1097/IAE.0000000000002934. Retina. 2021. PMID: 32769714 No abstract available.

References

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