Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;124(5):619-620.
doi: 10.1038/s41437-020-0314-z. Epub 2020 Apr 6.

Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy

Affiliations

Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy

Jeffrey D Jensen et al. Heredity (Edinb). 2020 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, Bolon DN, Zeldovich KB, Kowalik TF, Finberg RW, Wang JP, Jensen JD. An experimental evaluation of drug induced mutational meltdown as an antiviral treatment strategy. Evolution. 2016;70:2470–2484. doi: 10.1111/evo.13041. - DOI - PubMed
    1. Baranovich T, Wong SS, Armstrong J, Marjuki HJ, Webby RJ, Webster RG, Govorkova EA. T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro. J Virol. 2013;87:3741–3751. doi: 10.1128/JVI.02346-12. - DOI - PMC - PubMed
    1. Bull JJ, Sanjuan R, Wilke CO. Theory of lethal mutagenesis for viruses. J Virol. 2007;81:2930–2939. doi: 10.1128/JVI.01624-06. - DOI - PMC - PubMed
    1. Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19) Drug Disco Ther. 2020;14:58–60. doi: 10.5582/ddt.2020.01012. - DOI - PubMed
    1. Furuta Y, Gowen BB, Takahashi K, Shiraki K, Smee SF, Barnard DL. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antivir Res. 2013;100:446–454. doi: 10.1016/j.antiviral.2013.09.015. - DOI - PMC - PubMed

MeSH terms