. 2020 Jan-Feb;61(1):42-45.

doi: 10.1016/j.hjc.2020.03.002. Epub 2020 Apr 3.

The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Spyridon G Deftereos¹, Gerasimos Siasos², Georgios Giannopoulos³, Dimitrios A Vrachatis⁴, Christos Angelidis², Sotiria G Giotaki², Panagiotis Gargalianos⁵, Helen Giamarellou⁶, Charalampos Gogos⁷, Georgios Daikos⁸, Marios Lazanas⁹, Pagona Lagiou², Georgios Saroglou¹⁰, Nikolaos Sipsas², Sotirios Tsiodras², Dimitrios Chatzigeorgiou¹¹, Nikolaos Moussas⁵, Anastasia Kotanidou², Nikolaos Koulouris², Evangelos Oikonomou², Andreas Kaoukis³, Charalampos Kossyvakis³, Konstantinos Raisakis³, Katerina Fountoulaki¹², Mihalis Comis¹², Dimitrios Tsiachris⁵, Eleni Sarri², Andreas Theodorakis¹³, Luis Martinez-Dolz¹⁴, Jorge Sanz-Sánchez¹⁵, Bernhard Reimers¹⁶, Giulio G Stefanini¹⁶, Michael Cleman¹⁷, Dimitrios Filippou², Christoforos D Olympios¹², Vlasios N Pyrgakis³, John Goudevenos¹⁸, George Hahalis⁷, Theofilos M Kolettis¹⁸, Efstathios Iliodromitis², Dimitrios Tousoulis², Christodoulos Stefanadis¹⁹

Affiliations

¹ Medical School, National & Kapodistrian University of Athens, Athens, Greece. Electronic address: spdeftereos@gmail.com.
² Medical School, National & Kapodistrian University of Athens, Athens, Greece.
³ General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
⁴ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
⁵ Athens Medical Center, Athens, Greece.
⁶ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Therapeutirion Hygeia, Athens, Greece.
⁷ Medical School, University of Patras, Patra, Greece.
⁸ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Mitera Hospital, Athens, Greece.
⁹ Metropolitan General Hospital, Athens, Greece.
¹⁰ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Metropolitan Hospital, Athens, Greece.
¹¹ Hellenic Air Force General Staff.
¹² General Hospital of Elefsina "Thriasio", Elefsina, Greece.
¹³ Missolonghi General Hospital "Chatzikosta", Missolonghi, Greece.
¹⁴ Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁵ Humanitas Clinical and Research Institute, Rozzano, Milan, Italy; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁶ Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
¹⁷ Yale University School of Medicine, New Haven, CT, USA.
¹⁸ University of Ioannina, Ioannina, Greece.
¹⁹ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Athens Medical Center, Athens, Greece.

PMID: 32251729
PMCID: PMC7194546
DOI: 10.1016/j.hjc.2020.03.002

The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Spyridon G Deftereos et al. Hellenic J Cardiol. 2020 Jan-Feb.

. 2020 Jan-Feb;61(1):42-45.

doi: 10.1016/j.hjc.2020.03.002. Epub 2020 Apr 3.

Authors

Affiliations

¹ Medical School, National & Kapodistrian University of Athens, Athens, Greece. Electronic address: spdeftereos@gmail.com.
² Medical School, National & Kapodistrian University of Athens, Athens, Greece.
³ General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
⁴ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
⁵ Athens Medical Center, Athens, Greece.
⁶ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Therapeutirion Hygeia, Athens, Greece.
⁷ Medical School, University of Patras, Patra, Greece.
⁸ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Mitera Hospital, Athens, Greece.
⁹ Metropolitan General Hospital, Athens, Greece.
¹⁰ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Metropolitan Hospital, Athens, Greece.
¹¹ Hellenic Air Force General Staff.
¹² General Hospital of Elefsina "Thriasio", Elefsina, Greece.
¹³ Missolonghi General Hospital "Chatzikosta", Missolonghi, Greece.
¹⁴ Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁵ Humanitas Clinical and Research Institute, Rozzano, Milan, Italy; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁶ Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
¹⁷ Yale University School of Medicine, New Haven, CT, USA.
¹⁸ University of Ioannina, Ioannina, Greece.
¹⁹ Medical School, National & Kapodistrian University of Athens, Athens, Greece; Athens Medical Center, Athens, Greece.

PMID: 32251729
PMCID: PMC7194546
DOI: 10.1016/j.hjc.2020.03.002

Abstract

Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.

Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group.

Results: Trial results will be disseminated through peer-reviewed publications and conference presentations.

Conclusion: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).

Keywords: COVID; CRP; Cardiac; Complications; Troponin.

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Conflict of interest statement

Conflict of interest No conflict of interest exists.

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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

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