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. 2020 Jan-Feb;61(1):42-45.
doi: 10.1016/j.hjc.2020.03.002. Epub 2020 Apr 3.

The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Spyridon G Deftereos  1 , Gerasimos Siasos  2 , Georgios Giannopoulos  3 , Dimitrios A Vrachatis  4 , Christos Angelidis  2 , Sotiria G Giotaki  2 , Panagiotis Gargalianos  5 , Helen Giamarellou  6 , Charalampos Gogos  7 , Georgios Daikos  8 , Marios Lazanas  9 , Pagona Lagiou  2 , Georgios Saroglou  10 , Nikolaos Sipsas  2 , Sotirios Tsiodras  2 , Dimitrios Chatzigeorgiou  11 , Nikolaos Moussas  5 , Anastasia Kotanidou  2 , Nikolaos Koulouris  2 , Evangelos Oikonomou  2 , Andreas Kaoukis  3 , Charalampos Kossyvakis  3 , Konstantinos Raisakis  3 , Katerina Fountoulaki  12 , Mihalis Comis  12 , Dimitrios Tsiachris  5 , Eleni Sarri  2 , Andreas Theodorakis  13 , Luis Martinez-Dolz  14 , Jorge Sanz-Sánchez  15 , Bernhard Reimers  16 , Giulio G Stefanini  16 , Michael Cleman  17 , Dimitrios Filippou  2 , Christoforos D Olympios  12 , Vlasios N Pyrgakis  3 , John Goudevenos  18 , George Hahalis  7 , Theofilos M Kolettis  18 , Efstathios Iliodromitis  2 , Dimitrios Tousoulis  2 , Christodoulos Stefanadis  19
Affiliations

The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Spyridon G Deftereos et al. Hellenic J Cardiol. 2020 Jan-Feb.

Abstract

Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.

Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group.

Results: Trial results will be disseminated through peer-reviewed publications and conference presentations.

Conclusion: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).

Keywords: COVID; CRP; Cardiac; Complications; Troponin.

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Conflict of interest statement

Conflict of interest No conflict of interest exists.

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