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Case Reports
. 2020 Jun:95:174-175.
doi: 10.1016/j.ijid.2020.03.041. Epub 2020 Apr 3.

Evidence from two cases of asymptomatic infection with SARS-CoV-2: Are 14 days of isolation sufficient?

Ren Wan  1 , Zhi-Qun Mao  2 , Li-Yi He  3 , Yue-Chun Hu  3 , Wei-Chen  4
Affiliations
Case Reports

Evidence from two cases of asymptomatic infection with SARS-CoV-2: Are 14 days of isolation sufficient?

Ren Wan et al. Int J Infect Dis. 2020 Jun.

Abstract

Among 78 laboratory-confirmed cases, we found two asymptomatic infections. One patient was discharged within 14 days after treatment. Another patient was discharged 25 days after treatment, and his RT-PCR test was still positive on the 15th day. We found that there may be virus carriers in the asymptomatic population with an epidemiological contact history. After 14 days of isolation, those with asymptomatic infection may still carry the virus, which means a risk of transmission, presenting a new challenge for the management of home isolation.

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Figures

Figure 1
Figure 1
Timeline of RT-PCR testing.
Figure 2
Figure 2
Viral load detected in throat swabs. This shows cycle threshold (Ct) values for ORF1ab, from reverse-transcriptase polymerase chain reaction (RT-PCR) assays, detected in throat swabs obtained from the two patients. Ct values of 29.96, 26.64, 23.32, and 20 correspond to 1.0 × 104, 1.0 × 105, 1.0 × 106, and 1.0 × 107 copies per milliliter, respectively, and represent positive samples. Negative samples are represented by Ct values of more than 40.
See this image and copyright information in PMC

References

    1. Bai Y., Yao L., Wei T. Presumed asymptomatic carrier transmission of Covid-19. JAMA. Published online February 21, 2020. 2020 doi: 10.1001/Jama.2020.2565. - DOI - PMC - PubMed
    1. Hoehl S., Rabenau H., Berger A. Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China. N Engl J Med. 2020 doi: 10.1056/NEJMc2001899. - DOI - PMC - PubMed
    1. Li Q., Guan X., Wu P. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020 doi: 10.1056/NEMoa2001316. - DOI - PMC - PubMed
    1. Lipsitch M., Swerdlow D.L., Finelli L. Defining the epidemiology of Covid-19-studies needed. N Engl J Med. 2020 doi: 10.1056/NEJMp2002125. - DOI - PubMed
    1. WHO . 2020. Coronavirus disease (COVID-19) advice for the public.https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-f... Available at:

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