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. 2020 Mar;24(1):3-11.
doi: 10.5213/inj.2040010.005. Epub 2020 Mar 31.

Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative

Michael B Chancellor  1 , Sarah N Bartolone  1 , Laura E Lamb  1 , Elijah Ward  1 , Bernadette M M Zwaans  1 , Ananias Diokno  1
Affiliations

Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative

Michael B Chancellor et al. Int Neurourol J. 2020 Mar.

Abstract

There is a significant need for research and understanding of underactive bladder (UAB). The International Congress of Urologic Research and Education on Aging UnderActive Bladder (CURE-UAB) was organized by Doctors Michael Chancellor and Ananias Diokno in order to address these concerns. CURE-UAB was supported, in part, by the US National Institute of Aging and National Institute of Diabetes Digestive and Kidney. Since 2014, there have been 5 successful CURE-UAB congresses. They have brought together diverse stakeholders in the UAB field to identify areas of major scientific challenge and initiated a call to action among the medical community. In this review, we will highlight current and novel treatments under development for UAB and the progress and impact from the CURE-UAB initiative.

Keywords: Aging; Overactive urinary bladder; Sarcopenia; Underactive urinary bladder; Urodynamics.

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Conflict of interest statement

Conflict of Interest

Michael B Chancellor is one of the inventors of the autologous muscle-derived cell process and has received royalty payments for the stem cell process and payments for consulting from Cook MyoSite. Except for that, no potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
The number of publications and grants on underactive bladder (UAB, A) and overactive bladder (OAB, B) over time (shown is 1998 to 2019). The CURE-UAB conference series started in 2014 and ended in 2019 (yellow box and shading). Publication count (UAB: orange line, right y-axis; OAB: blue line, right y-axis) is from PubMed.gov search of "underactive bladder" or “overactive bladder” on 12/17/19. Prior to 1998, there are only 38 publications total for underactive bladder, with the earliest one from 1980. Grant count (UAB: blue bars, left y-axis; OAB: green bars, left y-axis) is from Grantome.com search of "underactive bladder” or “overactive bladder” on 12/17/19. There were no grants on UAB reported before 2007. CURE-UAB, Congress of Urologic Research and Education on Aging UnderActive Bladder.
Fig. 2.
Fig. 2.
Several ways to consider the relationship between overactive bladder (OAB) and underactive bladder (UAB). (A) OAB and UAB as separate conditions. (B) OAB and UAB as overlapping syndromes. (C) OAB may progress to UAB.
Fig. 3.
Fig. 3.
The overactive bladder (OAB) to underactive bladder (UAB) hypothesis: patients with chronic untreated or treatment refractory OAB have a significant risk of progression to UAB.
See this image and copyright information in PMC

References

    1. van Koeveringe GA, Vahabi B, Andersson KE, Kirschner-Herrmans R, Oelke M. Detrusor underactivity: a plea for new approaches to a common bladder dysfunction. Neurourol Urodyn. 2011;30:723–8. - PubMed
    1. Osman NI, Chapple CR, Abrams P, Dmochowski R, Haab F, Nitti V, et al. Detrusor underactivity and the underactive bladder: a new clinical entity? A review of current terminology, definitions, epidemiology, aetiology, and diagnosis. Eur Urol. 2014;65:389–98. - PubMed
    1. Chancellor MB, Diokno AC. The underactive bladder. Cham (Switzerland): Springer International Publishing; 2016.
    1. Chancellor MB, Bartolone SN, DeVries EM, Diokno AC, Gibbons M, Jankowski R, et al. New technology assessment and current and upcoming therapies for underactive bladder. Neurourol Urodyn. 2018;37:2932–7. - PubMed
    1. Dewulf K, Abraham N, Lamb LE, Griebling TL, Yoshimura N, Tyagi P, et al. Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB) Int Urol Nephrol. 2017;49:777–85. - PubMed

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