Risk factors and outcomes of sepsis-associated delirium in intensive care unit patients: A secondary data analysis
- PMID: 32253122
- DOI: 10.1016/j.iccn.2020.102844
Risk factors and outcomes of sepsis-associated delirium in intensive care unit patients: A secondary data analysis
Abstract
Objective: To identify the risk factors of sepsis-associated delirium and determine their effect on intensive care unit adult patient outcomes.
Design: A secondary analysis of data from system development studies.
Setting: Korean intensive care unit patients in a university hospital who were diagnosed with sepsis.
Methods: The risk factors for sepsis-associated delirium were classified into patient factors and sepsis clinical features and were analysed using hierarchical logistic regression analysis. Outcomes included in-hospital mortality, 30-day in-hospital mortality, duration of mechanical ventilation, length of stay in the intensive care unit, length of hospital stay, total medical expenses, discharge placement, re-hospitalisation and visits to the emergency department after discharge.
Results: The risk factor for sepsis-associated delirium including patients aged 65 ≥years, dependent activity and high nursing needs (patient factors), low level of consciousness, tachypnoea, and thrombocytopaenia (clinical features of sepsis). Use of vasopressors/inotropes and albumin decreased the risk of sepsis-associated delirium. Mechanical ventilation duration was prolonged and discharge to skilled nursing facilities was increased by sepsis-associated delirium.
Conclusions: The risk factors for sepsis-associated delirium increased as the severity of condition for patients with sepsis increased. Early identification of risk factors associated with sepsis-associated delirium may improve patient outcomes.
Keywords: Delirium; Risk factors; Sepsis; Sepsis-associated encephalopathy; Treatment outcome.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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