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Case Reports
. 2020 May;35(5):1138-1141.
doi: 10.1111/jocs.14530. Epub 2020 Apr 6.

Nontuberculous mycobacterial infections in left ventricular assist device patients

Christopher Radcliffe  1 , Natnael Doilicho  1 , Matthew Grant  1   2
Affiliations
Case Reports

Nontuberculous mycobacterial infections in left ventricular assist device patients

Christopher Radcliffe et al. J Card Surg. 2020 May.

Abstract

Left ventricular assist devices (LVADs) are integral for the management of medically refractory heart failure, and LVAD infections are common following device placement. Most infections are caused by Staphylococcal spp. and Gram-negative enteric bacteria but nontuberculous mycobacterial (NTM) infections have been reported. We present the second-ever reported case of a driveline infection caused by Mycobacterium fortuitum in a 75-year-old male with a continuous-flow LVAD. After receiving meropenem, azithromycin, and ciprofloxacin, he underwent device exchange and ultimately died after failing to recover neurologically. Management of NTM infections presents a clinical challenge due to the propensity for rapidly growing mycobacterial species to form biofilms and the possibility of negative cultures delaying diagnosis. To address the literature gap surrounding NTM infections in LVAD patients, we performed a systematic review and present all previously reported cases.

Keywords: clinical review; transplant.

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References

REFERENCES

    1. Kormos RL, Cowger J, Pagani FD, et al. The Society of Thoracic Surgeons Intermacs database annual report: evolving indications, outcomes, and scientific partnerships. J Heart Lung Transplant. 2019;38(2):114-126.
    1. Hannan MM, Husain S, Mattner F, et al. Working formulation for the standardization of definitions of infections in patients using ventricular assist devices. J Heart Lung Transplant. 2011;30(4):375-384.
    1. Koval CE, Stosor V, AST ID Community of Practice. Ventricular assist device-related infections and solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13552.
    1. Nunez Breton JD, Hernandez G, Simkins J, Chaparro SV. Mycobacterium abscessus left ventricle assist device driveline infections: an emerging pathogen? Transpl Infect Dis. 2018;20(5):e12957.
    1. Roest S, Bax HI, Verkaik NJ, et al. Mycobacterium chelonae, an 'atypical' cause of an LVAD driveline infection. Int J Infect Dis. 2020;92:127-129.

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