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Review
. 2020 May;33(3):e13380.
doi: 10.1111/dth.13380. Epub 2020 Apr 16.

Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine

Robert A Schwartz  1 , Camila K Janniger  1
Affiliations
Review

Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine

Robert A Schwartz et al. Dermatol Ther. 2020 May.

Abstract

A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. We delineate it as generalized pustular figurate erythema.

Keywords: COVID-19; DRESS syndrome; SARS-2; SARS-CoV-2; Stevens-Johnson syndrome; Sweet syndrome; acute generalized exanthematous pustulosis; coronavirus; drug rash; erythema multiforme; figurate erythema; hydroxychloroquine; toxic epidermal necrolysis; urticaria.

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Conflict of interest statement

The authors declare no potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Hydroxychloroquine‐induced GPFE with numerous nonfollicular pustules atop atypical targetoid plaques. GPFE, generalized pustular figurate erythema
See this image and copyright information in PMC

Comment in

References

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