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Comment
. 2020 Jun;14(6):1121-1123.
doi: 10.1002/1878-0261.12679. Epub 2020 Apr 21.

RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers

Kajal Biswas  1 , Shyam K Sharan  1
Affiliations
Comment

RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers

Kajal Biswas et al. Mol Oncol. 2020 Jun.

Abstract

Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2-mediated DNA repair by homologous recombination and RAD52-mediated single-strand annealing may result in cell death and reduce breast cancer risk. Comment on: https://doi.org/10.1002/1878-0261.12665.

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

References

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