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. 2020 Dec;92(12):3689-3696.
doi: 10.1002/jmv.25811. Epub 2020 Apr 25.

The aim of the measurement of Epstein-Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites

Tomoko Miyake  1 , Keiji Iwatsuki  1 , Yoji Hirai  1 , Takenobu Yamamoto  1   2 , Toshihisa Hamada  1   3 , Kazuyasu Fujii  1   4 , Hideaki Imamura  5 , Shin Morizane  1
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Free article

The aim of the measurement of Epstein-Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites

Tomoko Miyake et al. J Med Virol. 2020 Dec.
Free article

Abstract

Epstein-Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut-off level. Of 16 plasma samples, extremely high in two samples obtained from patients with hemophagocytic lymphohistiocytosis (HLH). The amount of cell-free DNA in plasma was correlated to the serum levels of lactate dehydrogenase and inversely correlated to platelet counts. These results indicate that the EBV DNA load in PBMCs can provide one of the diagnostic indicators for HV and HMB and marked elevation of cell-free EBV DNA in plasma might be related to cytolysis such as that observed in HLH.

Keywords: Epstein-Barr virus DNA load; hemophagocytic lymphohistiocytosis; hydroa vacciniforme; hypersensitivity to mosquito bite.

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