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. 2020 Jul 20;38(21):2454-2462.
doi: 10.1200/JCO.20.00199. Epub 2020 Apr 7.

Breast Cancer: 45 Years of Research and Progress

Gabriel N Hortobagyi  1
Affiliations

Breast Cancer: 45 Years of Research and Progress

Gabriel N Hortobagyi. J Clin Oncol. .
No abstract available

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Conflict of interest statement

Breast Cancer: 45 Years of Research and Progress

The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Gabriel N. Hortobagyi

Consulting or Advisory Role: Novartis, Peregrine Pharmaceuticals, Agendia

Research Funding: Novartis (Inst)

Travel, Accommodations, Expenses: Novartis

No other potential conflicts of interest were reported.

Figures

FIG 1.
FIG 1.
History of breast cancer treatment: Timeline. Integration of various discoveries that led to changes in the standard of care. Discoveries are displayed by approximate year of incorporation into practice. AI, aromatase inhibitor; APBI, accelerated partial breast irradiation; IMRT, intensity-modulated radiotherapy; LHRH, luteinizing hormone-releasing hormone; RT, radiotherapy; SERM, selective estrogen receptor modulator; T-DM1, trastuzumab emtansine.
FIG 2.
FIG 2.
Systemic management of primary breast cancer. The four generally accepted clinical-molecular subtypes are shown, along with standard-of-care therapeutic approaches to each subtype. AI, aromatase inhibitor; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor; RS, recurrence score; SERM, selective estrogen receptor modulator.
FIG 3.
FIG 3.
Five-year relative survival rates for breast cancer: 1973-2019. Numbers represent 5-year relative survival figures. The change between 1973 and 2019 reflects the progress in detection and treatment. Data are given as percent 5-year survival.
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