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. 2020 Apr;70(2):119-125.
doi: 10.1007/s13224-019-01289-1. Epub 2019 Dec 14.

The Effect of Vitamin D Supplementation on Improving Glycaemic Control in Diabetic Vitamin D-Deficient Pregnant Women: A Single-Blinded Randomized Control Trial

R V Bhavya Swetha  1 , Rajnish Samal  1 , Carolin Elizabeth George  2
Affiliations

The Effect of Vitamin D Supplementation on Improving Glycaemic Control in Diabetic Vitamin D-Deficient Pregnant Women: A Single-Blinded Randomized Control Trial

R V Bhavya Swetha et al. J Obstet Gynaecol India. 2020 Apr.

Abstract

Introduction: Gestational diabetes mellitus is one of the most common conditions complicating pregnancy. Vitamin D deficiency is closely associated with gestational diabetes mellitus.

Objectives: To study the effect of vitamin D supplementation on diabetic pregnant women with vitamin D deficiency.

Methods: This randomized controlled study was conducted with 100 diabetic pregnant women. They were randomized into group A and group B. Group A were screened for vitamin D deficiency once diagnosed with GDM of which 40 were found to be deficient and allotted to group D (n = 40) and were supplemented with 60,000 units of vitamin D3 per month. Group B were given routine antenatal care and were screened for vitamin D deficiency when they were admitted for delivery, and 39 of them were found to have vitamin D deficiency and were studied as control group C (n = 39). Ten women in both the groups had normal levels of vitamin D, and one of them was excluded from the study as she had molar pregnancy. The vitamin D supplemented group D and the control group C were matched for age and parity at the baseline.

Results: There was a significant increase in the mean insulin and metformin requirements in both the supplemented and control groups. Vitamin D supplementation did not improve the glycaemic control in diabetic pregnant women.

Conclusion: Vitamin D supplementation did not decrease insulin resistance or improve the glycaemic control in diabetic pregnant women with vitamin D deficiency.

Keywords: Gestational diabetes mellitus; Glycaemic control; Neonatal outcomes; Vitamin D deficiency; Vitamin D supplementation.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Summary of the study design
Fig. 2
Fig. 2
Glycaemic control in interventional versus control group
Fig. 3
Fig. 3
Mean requirement of insulin and metformin in group D versus group C
See this image and copyright information in PMC

References

    1. Mishra S, Bhadoria AS, Kishore S, et al. Gestational diabetes mellitus 2018 guidelines: an update. J Fam Med Prim Care. 2018;7(6):1169–1172. doi: 10.4103/jfmpc.jfmpc_178_18. - DOI - PMC - PubMed
    1. Rodrigues MRK, Lima SAM, Mazeto GMFDS, et al. Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials. PLoS ONE. 2019;14(3):e0213006. doi: 10.1371/journal.pone.0213006. - DOI - PMC - PubMed
    1. Hu Z, Chen JA, Sun X, et al. Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients. New Engl J Med. 2019;98(14):520–530. - PMC - PubMed
    1. Bener A, Al-Hamaq A, Saleh N. Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons. Int J Women’s Health. 2013;5:523. doi: 10.2147/IJWH.S51403. - DOI - PMC - PubMed
    1. Parildar H, Unal A, Desteli G, et al. Frequency of vitamin D deficiency in pregnant diabetics at Baskent University Hospital, Istanbul. Pak J Med Sci. 2013;29:15–20. - PMC - PubMed

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