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. 1988 Dec;88(1-3):145-50.
doi: 10.1016/0022-510x(88)90212-2.

Absence of linkage with the Duffy blood group in a family with Charcot-Marie-Tooth neuropathy

P Raeymaekers  1 , P De Jonghe, L Swerts, L Muylle, J Gheuens, J J Martin, C Van Broeckhoven, A Vandenberghe
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Absence of linkage with the Duffy blood group in a family with Charcot-Marie-Tooth neuropathy

P Raeymaekers et al. J Neurol Sci. 1988 Dec.

Abstract

We report a large Belgian family with Charcot-Marie-Tooth disease (CMT) or hereditary motor and sensory neuropathy type I (HMSN-I). The pedigree consists of 5 generations with 350 family members comprising 42 patients. The disease is transmitted according to an autosomal dominant inheritance pattern. Several HMSN-I families have been reported to be closely linked to the Duffy blood group marker on chromosome 1. These families were designated HMSN-Ib families, opposed to the HMSN-Ia families which do not show evidence for such a linkage. Therefore we examined our family for the Duffy linkage relationship. We found no evidence for a strong linkage of the disease to the Duffy blood group locus, indicating that this family is of genetic subtype Ia.

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