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. 2020 Jan 17:2020:3417329.
doi: 10.1155/2020/3417329. eCollection 2020.

Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism

E Dozio  1 , E Passeri  2 , E Vianello  1 , S Palmieri  3 , C Eller-Vainicher  3 , M Corsi Romanelli  1   4 , S Corbetta  2   5
Affiliations

Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism

E Dozio et al. Mediators Inflamm. .

Abstract

Background: Primary hyperparathyroidism (PHPT) is a common cause of secondary osteoporosis in postmenopausal women. Th17 lymphocytes and the released cytokine IL-17A play an important role in bone metabolism. Th17 cells have been shown to be activated by PTH, and peripheral blood T cells from patients affected with PHPT express higher levels of IL-17A mRNA than controls.

Aim: To investigate circulating levels of IL-17A and the ratio RANKL/OPG, as markers of osteoclastogenesis, in 50 postmenopausal PHPT women compared with postmenopausal osteoporotic non-PHPT women (n = 20).

Results: Circulating levels of IL-17A were similarly detectable in most PHPT and non-PHPT osteoporotic women (12.9 (8.4-23.1) vs. 11.3 (8.3-14.3) pg/ml, median (range interquartile), P = 0.759), at variance with premenopausal women where IL-17A was undetectable. In PHPT women, any significant correlations could be detected between circulating IL-17A levels and PTH levels. Nonetheless, significant negative correlations between circulating IL-17A and ionized calcium levels (r = -0.294, P = 0.047) and urine calcium excretions (r = -0.300, P = 0.045) were found. Moreover, PHPT women were characterized by positive correlations between IL-17A levels and femur neck (r = 0.364, P = 0.021) and total hip (r = 0.353, P = 0.015) T-scores. Circulating IL-17A levels did not show any significant correlation with sRANKL, OPG, and sRANKL/OPG ratio in PHPT women.

Conclusions: In postmenopausal PHPT women, circulating IL-17A levels were similar to those detected in postmenopausal non-PHPT women, showing a disruption of the relationship observed in postmenopausal osteoporosis among circulating PTH, sRANKL, OPG, IL-17A, and bone demineralization in postmenopausal PHPT women. The data support an osteogenic effect of IL-17A in postmenopausal PHPT women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Circulating IL-17A levels in postmenopausal PHPT women (black circles) compared with postmenopausal non-PHPT women (controls; black squares). (b) Correlation between circulating IL-17A levels and log PTH levels in PHPT women.
Figure 2
Figure 2
(a) Correlation between circulating IL-17A and plasma ionized calcium levels in PHPT women. (b) Correlation between circulating IL-17A and urine calcium excretion levels in PHPT women.
Figure 3
Figure 3
(a) Correlation between circulating IL-17A and femur neck T-scores in PHPT women. (b) Correlation between circulating IL-17A and total hip T-scores in PHPT women. (c) Correlation between circulating IL-17A and lumbar T-scores in PHPT women.
See this image and copyright information in PMC

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