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Review
. 2020 Mar 14:2020:2172740.
doi: 10.1155/2020/2172740. eCollection 2020.

A Comprehensive Review on Schisandrin B and Its Biological Properties

M I Nasser  1 , Shuoji Zhu  1 , Chen Chen  1 , Mingyi Zhao  1 , Huanlei Huang  1 , Ping Zhu  1
Affiliations
Review

A Comprehensive Review on Schisandrin B and Its Biological Properties

M I Nasser et al. Oxid Med Cell Longev. .

Abstract

Nature is a vast source of bioactive molecules and has provided an active and efficient reservoir for drug discovery. Among natural compounds, one of the most promising is Schisandrin B (Sch B), isolated from Schisandra chinensis, which was documented to possess diversified pharmacokinetic propriety, among them antioxidant, anti-inflammation, cardioprotection, and neuroprotection. Due to its large biological properties, Sch B was recorded to be a potent cure for several diseases by targeting several signaling pathways. This review is aimed at emphasizing the recent data on the biological properties of Sch B among the molecular mechanism of this drug on tumoral, cardiac, and neural diseases. The data suggest that the antitumor activities of Sch B were mainly through apoptosis and cell cycle arrest at the diver's stage. It is reported that Sch B could be used as effective chemotherapy, neuroprotection, and cardioprotection since it possesses a spectrum of biological activities; however, further investigations on the mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural drug candidate.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1
Regulation of cell cycle.
Figure 2
Figure 2
Autodock calculation was performed to determine and compare the binding amino affinity of Sch A, B, and C to cyclins and CDKs that control the cell cycle regulation.
Figure 3
Figure 3
Autodock calculation was performed to determine and compare the binding amino affinity of Sch A, B, and C to p53, Bax, Bcl-2, and caspase-3, which are the principal indicators of apoptosis.
Figure 4
Figure 4
Autodock calculation was performed to determine and compare the binding amino affinity of Sch A, B, and C to the protein that regulated apoptosis pathways.
Figure 5
Figure 5
Molecular mechanism of Schisandrin B.
See this image and copyright information in PMC

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