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Review
. 2020 Mar 24;11(12):1085-1095.
doi: 10.18632/oncotarget.27246.

The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis

Patricia Ferreira  1 , Rosimeire Aparecida Roela  1 , Rossana Veronica Mendoza Lopez  1 , Maria Del Pilar Estevez-Diz  1
Affiliations
Review

The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis

Patricia Ferreira et al. Oncotarget. .

Abstract

Objective: To accomplish a systematic review of literature with overall survival meta-analysis about the role of microRNA in epithelial ovarian cancer as prognostic and predictive factor to chemotherapy response. Methods: A search was conducted in the PubMed database, using the keywords "microRNA" and "ovarian cancer" or "miRNA" and "ovarian cancer". Original articles published before 02/02/2019 that had as main subject microRNA (miRNA) and ovarian cancer were included. We considered for inclusion only studies that associated microRNA to chemotherapy-related diagnosis, prognosis, or response in ovarian cancer. Results: The literature search returned 1,482 articles, 497 of which fulfilled inclusion criteria, yielding 350 miRNAs. The status of each miRNA was assessed in serum and tissue of ovarian cancer, benign tumors, and healthy tissue. The status of up-/downregulation of miRNAs was related to prognostic features (overall survival and disease-free survival) and response predictive features such as platinum and paclitaxel sensitivity/resistance. The miRNAs that had been cited three or more times were selected for prognostic and response predictive features analysis. Twelve miRNAs fulfilled all these criteria and were included in the overall survival meta-analysis. Conclusions: miRNAs affect virtually all mechanisms of carcinogenesis, working as either oncogenes or tumor suppressor genes. In this systematic review we identified miRNAs that may be related to prognosis, diagnosis, and chemotherapy sensitivity. The 12 miRNAs identified here should be included in future studies for validation.

Keywords: miRNA; microRNA; ovarian cancer; overall survival; prognostic factors.

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Conflict of interest statement

CONFLICTS OF INTEREST All the authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. miRNA in ovarian cancer.
Figure 2
Figure 2. Flowchart of identification and selection of articles to literature systematic review.
Figure 3
Figure 3. Flowchart of selection of miRNAs to overall survival meta-analysis.
Figure 4
Figure 4
(A) miRNA expression level decreased versus increased expression level correlated to overall survival. (B) miRNA and their respective status correlated to overall survival. OS: overall survival; up: upregulation; down: downregulation; miR: miRNA; ref: reference.
Figure 5
Figure 5
(A) Overall survival meta-analysis for miR-30 family (miRNA expression level decreased versus increased expression level). (B) Overall survival meta-analysis for miR-200 family (miRNA expression level decreased versus increased expression level). (C) Articles references of miRNA and their respective status correlated to OS. OS: overall survival; up: upregulation; down: downregulation; miR: miRNA; ref: reference.
See this image and copyright information in PMC

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