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Case Reports
. 2020 Mar 28;2020(3):rjaa037.
doi: 10.1093/jscr/rjaa037. eCollection 2020 Mar.

Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features

Lorenzo D'Alì  1 , Angelica Tulisso  1 , Laura Mariuzzi  1
Affiliations
Case Reports

Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features

Lorenzo D'Alì et al. J Surg Case Rep. .

Abstract

Mesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions.

Keywords: chondrosarcoma; mesenchymal; orbit.

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Figures

Figure 1
Figure 1
(A–D) Imaging features of MCS: CT scans demonstrated an ovoidal soft tissue mass with central calcification (A), T2 (B) and T1 (C) weighted images showing an oval tumor with iso-hyperintense signal with a calcified central component. Enhanced T1 weighted image demonstrating an omogenous tumoral enhancement except for the central calcified part (D).
Figure 2
Figure 2
Low-power view of the lesion showing central ossification (H&E).
Figure 3
Figure 3
Abrupt transition from small cell component to well differentiated cartilaginous area (H&E, high power view).
Figure 4
Figure 4
Typical hemangiopericytoma-like vascular pattern (H&E, high power view).
Figure 5
Figure 5
Immunohistochemical features of MCS: cytoplasmic positivity for CD99 in the small cell component (IHC stain).
Figure 6
Figure 6
Nuclear positivity for S100 in the cartilaginous component (IHC stain).
See this image and copyright information in PMC

References

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