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Review
. 2020 Mar 19:2020:6108362.
doi: 10.1155/2020/6108362. eCollection 2020.

The Role of IL-33 in Experimental Heart Transplantation

Jie Chen  1 , Yan He  2 , Zhongming Xie  1 , Yingying Wei  2 , Lihua Duan  3
Affiliations
Review

The Role of IL-33 in Experimental Heart Transplantation

Jie Chen et al. Cardiol Res Pract. .

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 family of proteins that are produced by a variety of cell types in multiple tissues. Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an "alarmin" upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment. To date, numerous studies have investigated the roles of IL-33 in human and murine models of diseases of the nervous system, digestive system, pulmonary system, as well as other organs and systems, including solid organ transplantation. With graft rejection and ischemia-reperfusion injury being the most common causes of grafted organ failure or dysfunction, researchers have begun to investigate the role of IL-33 in the immune-related mechanisms of graft tolerance and rejection using heart transplantation models. In the present review, we summarize the identified roles of IL-33 as well as the corresponding mechanisms by which IL-33 acts within the progression of graft rejection after heart transplantation in animal models.

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Conflict of interest statement

The authors declare that the research is conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

References

    1. Christie J. D., Edwards L. B., Kucheryavaya A. Y., et al. The registry of the international society for heart and lung transplantation: twenty-seventh official adult lung and heart-lung transplant report-2010. The Journal of Heart and Lung Transplantation. 2010;29(10):1104–1118. doi: 10.1016/j.healun.2010.08.004. - DOI - PubMed
    1. Lv Q., Li C., Mo Y., He L. The role of HMGB1 in heart transplantation. Immunology Letters. 2018;194:1–3. doi: 10.1016/j.imlet.2017.11.014. - DOI - PubMed
    1. Dallman M. J. Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult. Current Opinion in Immunology. 1995;7(5):632–638. doi: 10.1016/0952-7915(95)80069-7. - DOI - PubMed
    1. Ring G. H., Saleem S., Dai Z., et al. Interferon-γ is necessary for initiating the acute rejection of major histocompatibility complex class ii-disparate skin allografts. Transplantation. 1999;67(10):1362–1365. doi: 10.1097/00007890-199905270-00012. - DOI - PubMed
    1. Konieczny B. T., Dai Z., Elwood E. T., et al. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. The Journal of Immunology. 1998;160(5):2059–2064. - PubMed

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