Hypolipidemic and Hepatoprotective Effects of High-Polydextrose Snack Food on Swiss Albino Mice

Abstract

In this study, the hepatoprotective and hypolipidemic effects of high-polydextrose snack food on Swiss albino mice were investigated. The mice were randomly divided into three groups: control diet, high-fat diet, and high-fat and fiber diet groups. Addition of high-polydextrose snack to the high-fat diet resulted in significant reduction in the liver weight, the accumulation of lipid droplets in liver, and the liver damage of hyperlipidemic mice in comparison with the high-fat diet. The high-polydextrose snack also decreased the content of total triglyceride, cholesterol, and low-density lipoprotein cholesterol as well as the alanine aminotransferase and aspartate aminotransferase activities in the mice serum. In addition, the high-polydextrose snack significantly increased the high-density lipoprotein cholesterol content of the hyperlipidemic mice. Consequently, use of high-polydextrose snack generated hepatoprotective and hypolipidemic effects on hyperlipidemic mice.

Figure 1

Daily feed and energy intake of Swiss albino mice during the twelve-week experiment (CD: control diet group, HFD: high-fat diet group, and HFFD: high-fat and fiber diet group). The data are mean value ± standard deviation (n = 5). Values with different small letters in the figure are significantly different (p < 0.05).

Figure 2

Histological analysis of epididymal fat tissue of three groups. Epididymal adipose segment; the tissues were magnified by 200 times: (a) control diet group; (b) high-fat diet group; (c) high-fat and fiber diet group.

Figure 3

Micrographs of liver tissue of mice for 3 groups (×100): (a) control diet group; (b) high-fat diet group; (c) high-fat diet and fiber diet group.