[Asynchronism in the synthesis of antibodies directed against different antigenic sites of a macromolecule]
[Article in
French]
- PMID: 322577
Item in Clipboard
[Asynchronism in the synthesis of antibodies directed against different antigenic sites of a macromolecule]
[Article in
French]
Ann Immunol (Paris).
1977 Jan-Mar.
Abstract
"Activating" and "precipitating" antibodies elicited by Escherichia coli beta-D-galactosidase can be isolated by assortment of the respective antibody-forming cells in vitro, showing that the two antibodies have different specificities. Both populations also segregate in vivo and are synthesized asynchronously. The interplay of different antibody species with the same immunogenic molecule and the role of these expected to be complex interactions in the regulation of the immune response is an area for further investigation.
Similar articles
-
Long-term antibody synthesis in vitro- IV. Independent segregation of antibodies directed to different determinants of an antigen molecule in its native configuration.Immunology. 1976 Oct;31(4):553-61. Immunology. 1976. PMID: 61938 Free PMC article.
-
Association constant and heterogeneity index of antibodies specific for a natural determinant of a bacterial protein. Time-course studies during the in vitro immune response to a distinct site of Escherichia coli beta-D-galactosidase.J Immunol. 1974 Sep;113(3):756-63. J Immunol. 1974. PMID: 4137548 No abstract available.
-
In vitro antibody response to a distinct antigenic determinant of Escherichia coli beta-D-galactosidase. Effect of antigen dosage and co-cultivation of lymph node fragments on peak titres and duration of antibody synthesis.Immunology. 1974 Jul;27(1):43-52. Immunology. 1974. PMID: 4136807 Free PMC article.
-
Requirement of the immunogen (E. coli beta-galactosidase) for the response towards a determinant responsible for antibody-mediated enzyme activation, while antibodies binding some other site can be elicited by mitogen alone.Eur J Immunol. 1981 Apr;11(4):286-90. doi: 10.1002/eji.1830110404. Eur J Immunol. 1981. PMID: 6166479
-
Antigenesis and molecular differentiation.J Theor Biol. 1965 Sep;9(2):125-55. doi: 10.1016/0022-5193(65)90105-0. J Theor Biol. 1965. PMID: 5336574 Review. No abstract available.