doi: 10.1002/jps.2600770916.
Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients
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- PMID: 3225775
- DOI: 10.1002/jps.2600770916
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Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients
J Pharm Sci.
1988 Sep.
Abstract
The distribution into human milk lipid of 16 drugs with widely varying lipophilicity is reported. There is a high degree of correlation between milk lipid-ultrafiltrate and octanol-water partition coefficients, measured at 37 degrees C, provided digoxin and prednisolone are excluded. These steroid-based molecules may interact with free fatty acids in milk, forming micelles and thus perturbing the milk lipid-ultrafiltrate relationship. Equations are described which enable estimation of drug distribution into milk for lipid-soluble drugs, based on drug pKa and octanol-water partition coefficients.
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