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. 2019 Jul 24:35:7.
doi: 10.1186/s42826-019-0006-0. eCollection 2019.

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Bon-Sang Koo #  1 , Dong-Ho Lee #  2 , Philyong Kang  3 , Kang-Jin Jeong  1 , Sangil Lee  2 , Kijin Kim  2 , Youngjeon Lee  1   4 , Jae-Won Huh  1   4 , Young-Hyun Kim  1   4 , Sang-Je Park  1 , Yeung Bae Jin  1 , Sun-Uk Kim  3   4 , Ji-Su Kim  2   4 , Yeonghoon Son  2 , Sang-Rae Lee  1   4
Affiliations

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Bon-Sang Koo et al. Lab Anim Res. .

Abstract

Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and biochemical reference intervals for healthy cynomolgus and rhesus monkeys anesthetized with ketamine hydrochloride. A total of 142 cynomolgus monkeys (28 males and 114 females) and 42 rhesus monkeys (22 males and 20 females) were selected and analyzed in order to examine reference intervals of 20 hematological and 16 biochemical parameters. The effects of sex were also investigated. Reference intervals for hematological and biochemical parameters were separately established by species (cynomolgus and rhesus) and sex (male and female). No sex-related differences were determined in erythrocyte-related parameters for cynomolgus and rhesus monkey housed in indoor laboratory conditions. Alkaline phosphatase and gamma glutamyltransferase were significantly lower in females than males in both cynomolgus and rhesus monkeys aged 48-96 months. The reference values for hematological and biochemical parameters established herein might provide valuable information for researchers using cynomolgus and rhesus monkeys in experimental conditions for biomedical studies.

Keywords: Biochemistry; Cynomolgus monkey; Hematology; Non-human primate; Rhesus monkey.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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