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Case Reports
. 2020 Feb 28:8:77.
doi: 10.3389/fped.2020.00077. eCollection 2020.

Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report

Zineb Alfath  1 , Asmaa Ferdjallah  2 , Emily Greengard  2 , Sabeen K Askari  3 , Karim T Sadak  2 , Colleen K Correll  4
Affiliations
Case Reports

Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report

Zineb Alfath et al. Front Pediatr. .

Abstract

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis affecting children. It is managed in the outpatient setting and rarely associated with malignancy. We present a case of neuroblastoma in a 7-year-old boy diagnosed after suspected HSP. Our case highlights the importance of maintaining a broad differential diagnosis in children with atypical HSP and performing a skin biopsy with immunofluorescence when a rash is present.

Keywords: Henoch-Schönlein purpura; case report; neuroblastoma; pediatrics; rash.

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Figures

Figure 1
Figure 1
Mild leukoerythroblastic reaction seen on peripheral blood smear with slightly left-shifted granulocyte series and rare circulating nucleated red blood cells. (A) A granulocyte precursor is seen at the center of the field (100×). (B) A nucleated red blood cell is seen at the center of the field (100×).
Figure 2
Figure 2
Timeline in days of clinical symptoms of HSP and eventual progression to neuroblastoma diagnosis. Cr, creatinine; Hgb, hemoglobin; UA, urinalysis.
See this image and copyright information in PMC

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