Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 11;7(1):92-99.
doi: 10.3934/publichealth.2020009. eCollection 2020.

Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial

Safa Sadaghiani  1 , Soghra Fallahi  2 , Hossein Heshmati  2 , Saeed Hosseini Teshnizi  3 , Hooshang Abedini Chaijan  4 , Fahimeh Farzad Amir Ebrahimi  4 , Farhad Khorrami  4 , Mina Poorrezaeian  4 , Faezeh Alizadeh  4
Affiliations

Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial

Safa Sadaghiani et al. AIMS Public Health. .

Abstract

Introduction: Naturally, in human body, there is a balance between free radicals and the antioxidant system. Yet, cigarette consumption in smokers increases free radicals and decreases antioxidants. A vast body of research showed that the ROS level of seminal fluid is reduced using oral antioxidant complements through enhancing the clearing capacity of free radicals. Thus, the present research aimed to explore the effect of vitamin complement consumption on changing male infertility indices among smokers.

Methods: In the present randomized clinical trial which was single-blinded, 50 infertile oligospermic and asthenospermic men participated. They were selected in a randomized convenient sampling method. Before the study began, a semen sample was taken from all participants for analysis. Subsequently, the patients received 30 mg of Q10 coenzyme, 8 mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid for a whole duration of 3 months on a daily basis (once a day) and 200 mg of selenium every other day after lunch. A second sample of seminal fluid was taken from patients and semen parameters were compared between the pre- and post-test. The relevant statistical analyses were conducted in SPSS.23.

Results: A comparison of pre-test and post-test results revealed that all sperm parameters including the volume, morphology, motion, count and progressive motility were significantly increased after the intervention (p ≥ 005). Moreover, a statistically significant improvement was observed in the pH and concentration of seminal fluid.

Conclusion: The present research showed that consuming vitamin complements (30 mg of Q10, mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid) once a day as well as 200 mg of selenium every other day can effectively improve the qualitative parameters (pH and concentration) and quantitative parameters (volume, motion, morphology, count and progressive motility) in infertile male smokers.

Keywords: ROS; antioxidant; clinical trial; smokers; sperm parameters.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 2010.
    1. Sarkhanian M. Investigation on the protective effect of vitamin E on spermatogenesis in adolescent and adult male rats exposed to cigarette smoke. Ahvaz Jundishapur University of Medical Sciences; 2011.
    1. Ghaffari MA, Rostami M. The effect of cigarette smoking on human sperm creatine kinase activity: as an ATP buffering system in sperm. Int J Fertil Steril. 2013;6:258. - PMC - PubMed
    1. Kayedi M. Revalence of smoking and its severity in infertile men referring to Imam Khomeini Hospital in Ahwaz: Jundishapur Ahwaz. 2017.
    1. Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503–507. - PubMed

LinkOut - more resources