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. 2020 Mar 21;7(3):ofaa102.
doi: 10.1093/ofid/ofaa102. eCollection 2020 Mar.

High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

Wei Cao  1 , Xiaosheng Liu  2 , Tao Bai  3 , Hongwei Fan  1 , Ke Hong  3 , Hui Song  3 , Yang Han  1 , Ling Lin  1 , Lianguo Ruan  3 , Taisheng Li  1
Affiliations

High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

Wei Cao et al. Open Forum Infect Dis. .

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.

Keywords: coronavirus disease 2019; high-dose intravenous immunoglobulin; immunomodulation.

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Figures

Figure 1.
Figure 1.
Chest computed tomography scan of patient 1 (A), patient 2 (B), and patient 3 (C) before and after high-dose intravenous immunoglobulin with days of illness.
See this image and copyright information in PMC

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