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Case Reports

. 2020 Mar 25;6(4):351-353.

doi: 10.1016/j.jdcr.2020.02.011. eCollection 2020 Apr.

Insulin-derived amyloidosis: The insulin ball, amyloidoma

Curt Samlaska¹, Sara Reber², Todd Murry³

Affiliations

Affiliations

¹ University of Nevada School of Medicine, Las Vegas, Nevada.
² Academic Dermatology of Nevada, Henderson, Nevada.
³ LMC Pathology Services, Las Vegas, Nevada.

PMID: 32258319
PMCID: PMC7103663
DOI: 10.1016/j.jdcr.2020.02.011

Case Reports

Insulin-derived amyloidosis: The insulin ball, amyloidoma

Curt Samlaska et al. JAAD Case Rep. 2020.

. 2020 Mar 25;6(4):351-353.

doi: 10.1016/j.jdcr.2020.02.011. eCollection 2020 Apr.

Authors

Curt Samlaska¹, Sara Reber², Todd Murry³

Affiliations

¹ University of Nevada School of Medicine, Las Vegas, Nevada.
² Academic Dermatology of Nevada, Henderson, Nevada.
³ LMC Pathology Services, Las Vegas, Nevada.

PMID: 32258319
PMCID: PMC7103663
DOI: 10.1016/j.jdcr.2020.02.011

No abstract available

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Figures

Fig 1 — Fig 1
A, Firm subcutaneous mass (13.0 cm) on palpation, left triceps region. B, Firm subcutaneous mass (8.0 cm) on palpation, right side of the lower abdomen. C, Bilateral firm palpable subcutaneous masses (10 cm each), proximal portion of the thighs. D, Polarized Congo red stain demonstrating apple-green–colored birefringence.

See this image and copyright information in PMC

References

1. Shiba M., Kitazawa T. Progressive insulin-derived amyloidosis in a patient with type 2 diabetes. Case Rep Plast Surg Hand Surg. 2016;3:73–76. - PMC - PubMed
1. Nagase T., Iwaya K., Iwaki Y. The insulin ball. Lancet. 2009;373:184. - PubMed
1. Grunes D., Rapkiewicz A., Simsir A. Amyloidoma secondary to insulin injection: cytologic diagnosis and pitfalls. Cytojournal. 2015;12:15. - PMC - PubMed
1. Storkel S., Schneider H.M., Muntefering H. Iatrogenic, insulin-dependent, local amyloidosis. Lab Invest. 1983;48:108–111. - PubMed
1. Dische F.E., Wernstedt C., Westermark P. Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient. Diabetologia. 1988;31:158–161. - PubMed

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